Two goals in 79 first-half seconds set Brentford on their way to a comfortable victory over Southampton.
Both sides began the day on 40 points but Brentford's victory moved the Bees up to 12th in the Premier League, 11 points clear of the bottom three.
They went in front when centre-back Pontus Jansson forced home Ivan Toney's cross from close range, before Yoane Wissa curled into the bottom corner from the edge of the penalty area moments later.
Kristoffer Ajer sealed the win in the second half when he skipped away from two Saints players in the area before poking the ball beyond Fraser Forster.
Despite the defeat, Southampton should be safe from relegation, with an eight-point cushion between themselves and 18th-placed Everton, although Saints have the fewest games remaining of any of the bottom six.
Saints limping over the line
Southampton were ninth in the table in February, but seven defeats in their last 10 Premier League games have sent them sliding down to 15th in the table.
Ralph Hasenhuttl's side have two tricky-looking fixtures to come against title-chasing Liverpool on Tuesday before a final-day trip to Leicester.
They still should have enough points to avoid worrying about the drop, but could face a nervy run-in if Everton, Burnley and Leeds pick up victories.
A poor start cost them here, with Brentford unlucky not to be more than two goals up in the opening half hour, when Wissa and Mathias Jensen both went close.
After that poor start, Saints did rally but were mainly restricted to efforts from distance, with home goalkeeper David Raya equal to efforts from James Ward-Prowse and Mohamed Elyounoussi either side of the break.
Brentford ending on a high
In contrast to their opponents, Brentford are ending the season in fine form after a run of six wins from nine games.
The attacking spark provided by January signing Christian Eriksen has certainly helped. The Denmark midfielder has been on the winning side in six of his eight starts for the club.
But Thomas Frank's side have been equally impressive defensively, keeping clean sheets in five of their last six home matches, including the last four in a row - making them just the fourth side to have such a run this season after Arsenal, Liverpool and Manchester City.
This result was never really in doubt after their quickfire early double, with Jansson doing well to divert the ball into the net after Toney had chested Eriksen's high, hanging corner to the far post.
Eriksen was involved in the second goal too, and when referee Michael Salisbury played the advantage after the Dane was fouled, Wissa picked up the loose ball and curled it into the corner.
The Bees killed off any remaining Saints resistance with 11 minutes left thanks to Ajer's fine turn and finish, and the hosts were able to comfortably see out the match.
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Player of the match
with an average of 8.63
Squad number21Player nameEriksen
Squad number17Player nameToney
Squad number11Player nameWissa
Squad number6Player nameNørgaard
Squad number43Player nameYoung-Coombes
Squad number18Player nameJansson
Squad number26Player nameBaptiste
Squad number10Player nameDasilva
Squad number3Player nameHenry
Squad number8Player nameJensen
Squad number20Player nameAjer
Squad number19Player nameMbeumo
Squad number29Player nameBech Sørensen
Squad number1Player nameRaya
Squad number17Player nameS Armstrong
Squad number44Player nameForster
Squad number8Player nameWard-Prowse
Squad number2Player nameWalker-Peters
Squad number18Player nameBroja
Squad number24Player nameElyounoussi
Squad number15Player namePerraud
Squad number9Player nameA Armstrong
Squad number6Player nameOriol Romeu
Squad number35Player nameBednarek
Squad number22Player nameSalisu
Squad number27Player nameDiallo
Squad number11Player nameRedmond
- 29Bech Sørensen
- 8JensenSubstituted forYoung-Coombesat 87'minutes
- 19MbeumoSubstituted forBaptisteat 81'minutes
- 11WissaSubstituted forDasilvaat 68'minutes
- 17S ArmstrongSubstituted forRomeuat 83'minutes
- 27DialloBooked at 17minsSubstituted forElyounoussiat 64'minutes
- 9A Armstrong
Match ends, Brentford 3, Southampton 0.
Second Half ends, Brentford 3, Southampton 0.
Attempt missed. Romain Perraud (Southampton) left footed shot from long range on the left is too high. Assisted by Oriol Romeu.
Armando Broja (Southampton) wins a free kick in the defensive half.
Foul by Mads Bech Sørensen (Brentford).
Kyle Walker-Peters (Southampton) wins a free kick in the defensive half.
Foul by Shandon Baptiste (Brentford).
Foul by Kyle Walker-Peters (Southampton).
Rico Henry (Brentford) wins a free kick in the defensive half.
Romain Perraud (Southampton) wins a free kick on the left wing.
Foul by Nathan Young-Coombes (Brentford).
Substitution, Brentford. Nathan Young-Coombes replaces Mathias Jensen.
Foul by Oriol Romeu (Southampton).
Mathias Jensen (Brentford) wins a free kick in the defensive half.
Substitution, Southampton. Oriol Romeu replaces Stuart Armstrong.
Attempt missed. Mohammed Salisu (Southampton) header from the centre of the box misses to the left. Assisted by James Ward-Prowse with a cross following a corner.
Corner, Southampton. Conceded by Mads Bech Sørensen.
Attempt blocked. Kyle Walker-Peters (Southampton) right footed shot from the right side of the box is blocked. Assisted by Stuart Armstrong.
Substitution, Brentford. Shandon Baptiste replaces Bryan Mbeumo.
Goal! Brentford 3, Southampton 0. Kristoffer Ajer (Brentford) right footed shot from the centre of the box to the centre of the goal. Assisted by Christian Nørgaard.
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